UDI, Onoriode Andrew, IKIMI, Charles German, EKAKITIE, Ofovwe Obruche

Citation: Udi O. A., Ikimi C. G., & Ekakitie O. O. (2024). Assessing the neuroprotective potential of Zingiber officinalis methanol extract. Frontline Professionals Journal, 1(1), 68–79.

ABSTRACT
Background:
Recent research has started to uncover the neuroprotective properties of ginger, specifically its methanol extract, suggesting that it may play a significant role in safeguarding neuronal cells against various forms of damage.
Methodology:
The methodology involved evaluating in vitro and in vivo experimental studies that assessed the extract’s effects on neuronal cell lines, animal models of neurodegeneration and clinical observations. The review considered various parameters, including antioxidant activity, anti-inflammatory effects, and mechanisms of action related to neuroprotection.
Results:
The findings indicate that Zingiber officinalis methanol extract possesses significant neuroprotective potential, attributed to its rich phytochemical composition, including gingerol, shogaol, and other bioactive compounds. In vitro studies demonstrated that the extract can reduce oxidative stress and inflammation in neuronal cells. In vivo studies provided evidence of improved cognitive function. The results suggest that Zingiber officinalis methanol extract may be a promising candidate for neuroprotective therapy. The mechanisms underlying its protective effects appear to involve the modulation of oxidative stress and inflammatory responses, as well as the enhancement of neurotrophic factor signaling.
Conclusion:
Zingiber officinalis methanol extract exhibits significant neuroprotective properties, making it a candidate for further research in the context of neurodegenerative disease prevention and treatment.
Keywords:
Zingiber officinalis, ginger, neuroprotection, neurodegenerative diseases

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